Investigating how lung immune cells are affected by toxins in veterans
The Role of Macrophages in Deployment-related Lung Disease in OEF/OIF/OND Veterans
This study is looking at how harmful substances that veterans might encounter during military service affect their lung health, especially the immune cells that help protect their lungs, and it aims to find better ways to diagnose and treat lung diseases related to their service.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11052178 on NIH RePORTER |
What this research studies
This research focuses on understanding how exposure to harmful substances during military deployment affects lung immune cells, specifically macrophages, in veterans. It aims to identify the specific toxins that contribute to lung diseases and how these immune cells become dysfunctional over time. By studying these changes, the research seeks to develop better diagnostic criteria and potential therapies for veterans suffering from deployment-related lung disease. The approach includes analyzing lung tissue samples and testing targeted treatments in preclinical models.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have experienced deployment-related respiratory exposures and are exhibiting symptoms of lung disease.
Not a fit: Patients who have not served in the military or those without deployment-related respiratory symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for veterans suffering from chronic lung diseases related to their military service.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Soloff, Adam Christopher — Veterans Health Administration
- Study coordinator: Soloff, Adam Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.