Investigating how lung development affects respiratory diseases
Lung Development and Diseases
This study is looking at how a specific protein affects lung development, which could help us understand breathing problems that some babies are born with, by using mice to see what happens when this protein is missing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11023093 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Bone Morphogenetic Protein (BMP) signaling in the development of the lungs and its implications for congenital respiratory diseases. By using a specialized genetic tool to study lung mesenchyme, the researchers aim to uncover how disruptions in BMP signaling lead to abnormal lung structures and functions. The study involves creating knockout mice to observe the effects of BMP receptor deletion on airway branching and smooth muscle cell growth, which can provide insights into similar conditions in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children with congenital respiratory diseases or those at risk due to abnormal lung development.
Not a fit: Patients with respiratory diseases unrelated to congenital lung development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital respiratory diseases in newborns.
How similar studies have performed: Previous research has shown that understanding BMP signaling is crucial in lung development, indicating that this approach has potential for significant findings.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Shi, Wei — University of Cincinnati
- Study coordinator: Shi, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.