Investigating how lung cells contribute to cancer spread
Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation
['FUNDING_R01'] · JACKSON LABORATORY · NIH-11056697
This study is looking at how certain cells in the lungs help create a friendly environment for cancer cells to spread, especially in breast cancer, and it hopes to find new ways to stop this from happening so that patients can have better treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11056697 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of lung resident mesenchymal cells in the formation of a pre-metastatic niche, which is a supportive environment for cancer cells to spread to the lungs. By studying how these cells interact with immune cells, the research aims to uncover mechanisms that allow tumors to evade the immune system. The approach involves using mouse models of breast cancer to observe these interactions and their effects on tumor progression. The findings could lead to new strategies for preventing or treating lung metastases in cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with late-stage breast cancer who are at risk of developing lung metastases.
Not a fit: Patients with early-stage breast cancer or those whose cancer has not spread may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the spread of breast cancer to the lungs, improving survival rates for patients.
How similar studies have performed: Other research has shown promising results in understanding the immune environment in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REN, GUANGWEN — JACKSON LABORATORY
- Study coordinator: REN, GUANGWEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell, breast cancer metastasis