Investigating how lung cells affect immune responses in asthma
Official title: Targeting the stromal niche for tissue-resident lymphocytes in asthma
Funded at University of California, San Francisco · NIH-11024952 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs affect the immune response in people with allergic asthma, and it hopes to find new ways to reduce inflammation and help improve breathing for asthma patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $636,843 |
| NIH project number | 1R01HL176803-01 |
| Project ID | NIH-11024952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with allergic asthma, particularly those experiencing significant airway inflammation.
✕Less likely to help
Patients with non-allergic asthma or those who do not have significant airway inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of stromal cells in the lungs and how they influence the immune response during allergic asthma. By using advanced genetic tools and human organoid models, the team aims to identify specific factors produced by these stromal cells that can alter the accumulation of immune cells in the airways. The goal is to explore whether targeting these stromal factors can lead to new therapeutic strategies for reducing inflammation and improving airway function in asthma patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control asthma symptoms and reduce airway inflammation.
How similar studies have gone: While the approach of targeting stromal cells in asthma is relatively novel, preliminary data suggest that similar strategies may have shown promise in other contexts.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Peng, Tien — University of California, San Francisco
- Study coordinator: Peng, Tien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.