Investigating how lung cancer cells adapt and change
Official title: Targeting plasticity in lung cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11011270 · Data updated 2026-11-12
This study is looking at how lung adenocarcinoma, a tough type of lung cancer, changes in response to treatments, with the hope of finding better ways to target these adaptable cancer cells and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $611,289 |
| NIH project number | 5R01CA270116-03 |
| Project ID | NIH-11011270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung adenocarcinoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of lung cancer or those who are not diagnosed with cancer may not benefit from this research.
What this research studies
This research focuses on lung adenocarcinoma, a common and aggressive form of lung cancer that poses significant treatment challenges. The study aims to understand how cancer cells can change their characteristics in response to treatment, which often leads to treatment failure. By using advanced techniques like genetically engineered mouse models and single-cell mRNA sequencing, researchers will identify specific cell states that contribute to this adaptability. The goal is to uncover new therapeutic strategies that can effectively target these plastic cancer cells and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively target lung cancer, potentially improving survival rates for patients.
How similar studies have gone: Previous research has shown promise in targeting cancer cell plasticity, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Tammela, Tuomas — Sloan-Kettering Inst Can Research
- Study coordinator: Tammela, Tuomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.