Investigating how lung blood vessel cells affect immune responses during injury and healing
Intravital Imaging and Physiology Core
This study is looking at how special cells in the lungs help control the immune system's response during lung injuries, and it's for anyone interested in understanding how our bodies heal or struggle when we have inflammation in the lungs.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10914673 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of pulmonary endothelial cells, which line the blood vessels in the lungs, in regulating immune responses during inflammatory lung injury. By using advanced imaging techniques, researchers will observe how these cells interact with immune cells like neutrophils and macrophages during injury and recovery. The study employs genetically altered mouse models to explore the signaling mechanisms that dictate whether the immune response promotes healing or exacerbates injury. This innovative approach aims to provide insights into the dynamic processes occurring in the lungs during inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory lung diseases, such as asthma or chronic obstructive pulmonary disease (COPD).
Not a fit: Patients with non-inflammatory lung conditions or those who do not have any lung-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung healing and reduce inflammation in patients with respiratory conditions.
How similar studies have performed: Previous research has shown success in using advanced imaging techniques to study immune responses in other tissues, suggesting potential for similar breakthroughs in lung research.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Tsukasaki, Yoshikazu — University of Illinois at Chicago
- Study coordinator: Tsukasaki, Yoshikazu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.