Investigating how LSD1 affects bone cell development
The epigenetic role of LSD1 in osteoclast differentiation
This study is looking at how a certain enzyme called LSD1 affects the growth of bone-resorbing cells, which could help us find new ways to treat bone diseases like osteoporosis and gum disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11168659 on NIH RePORTER |
What this research studies
This research explores the role of a specific enzyme, LSD1, in the development of osteoclasts, which are cells responsible for bone resorption. By understanding how LSD1 influences the differentiation and activity of these cells, the research aims to uncover new insights into conditions like osteoporosis and periodontal disease. The study employs advanced techniques to analyze the molecular mechanisms involved in osteoclast gene expression and differentiation. Patients may benefit from findings that could lead to new treatments for bone-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from osteoporosis or periodontal disease, particularly those over the age of 21.
Not a fit: Patients with conditions unrelated to bone health or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating osteoporosis and periodontal disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic factors in cell differentiation, suggesting that this approach may yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Astleford-Hopper, Kristina — University of Minnesota
- Study coordinator: Astleford-Hopper, Kristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.