Investigating how LRRK1 affects bone health and turnover
Official title: Molecular Mechanisms of LRRK1 Regulation of Bone Homeostasis
Funded at Loma Linda Veterans Assn Research & Educ · NIH-10757038 · Data updated 2026-11-12
This study is looking at a protein called LRRK1 to see how it affects bone health, which could help us find new treatments for osteoporosis and improve care for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda Veterans Assn Research & Educ NIH-funded |
| Lab location | 1 site (Redlands, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $312,631 |
| NIH project number | 5R01AR078843-03 |
| Project ID | NIH-10757038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with osteoporosis or related bone health issues.
✕Less likely to help
Patients with conditions unrelated to bone metabolism or those who do not have osteoporosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of LRRK1, a protein involved in bone metabolism, and how its regulation affects bone health. The study will utilize both in vivo and in vitro methods to explore how LRRK1 influences the function of osteoclasts, the cells responsible for bone resorption. By examining the phosphorylation of specific proteins, the researchers aim to uncover mechanisms that could lead to new treatments for conditions like osteoporosis. Patients may benefit from insights gained about bone health and potential new therapies.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for osteoporosis and other bone-related disorders.
How similar studies have gone: Previous research has shown promise in targeting similar molecular pathways for treating bone disorders, indicating potential for success in this area.
Where this research is happening
-
Loma Linda Veterans Assn Research & Educ
Redlands, United States Active
Researchers
- Principal investigator: Xing, Weirong — Loma Linda Veterans Assn Research & Educ
- Study coordinator: Xing, Weirong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.