Investigating how LRRK1 affects bone health and turnover
Molecular Mechanisms of LRRK1 Regulation of Bone Homeostasis
['FUNDING_R01'] · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · NIH-10757038
This study is looking at a protein called LRRK1 to see how it affects bone health, which could help us find new treatments for osteoporosis and improve care for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOMA LINDA VETERANS ASSN RESEARCH & EDUC (nih funded) |
| Locations | 1 site (REDLANDS, UNITED STATES) |
| Trial ID | NIH-10757038 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of LRRK1, a protein involved in bone metabolism, and how its regulation affects bone health. The study will utilize both in vivo and in vitro methods to explore how LRRK1 influences the function of osteoclasts, the cells responsible for bone resorption. By examining the phosphorylation of specific proteins, the researchers aim to uncover mechanisms that could lead to new treatments for conditions like osteoporosis. Patients may benefit from insights gained about bone health and potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with osteoporosis or related bone health issues.
Not a fit: Patients with conditions unrelated to bone metabolism or those who do not have osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for osteoporosis and other bone-related disorders.
How similar studies have performed: Previous research has shown promise in targeting similar molecular pathways for treating bone disorders, indicating potential for success in this area.
Where this research is happening
REDLANDS, UNITED STATES
- LOMA LINDA VETERANS ASSN RESEARCH & EDUC — REDLANDS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XING, WEIRONG — LOMA LINDA VETERANS ASSN RESEARCH & EDUC
- Study coordinator: XING, WEIRONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.