Investigating how LRP1 affects neural stem cells after a stroke
Official title: LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response
Funded at University of Texas Hlth Science Center · NIH-11057547 · Data updated 2026-11-12
This study is looking at how a protein called LRP1 affects the movement and function of brain cells that help heal after a stroke, with the hope of finding better ways to support recovery for stroke patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $76,375 |
| NIH project number | 3R01NS132778-02S1 |
| Project ID | NIH-11057547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced an ischemic stroke and are seeking innovative treatment options for recovery.
✕Less likely to help
Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of LRP1, a receptor that influences cell signaling, in the behavior of neural stem cells (NSCs) following an ischemic stroke. The study aims to explore how LRP1 affects the migration and function of NSCs, which are crucial for recovery after a stroke. By examining the effects of LRP1 on NSC responses to environmental cues, the research seeks to uncover new insights that could improve therapeutic strategies for stroke recovery. The methodology involves genetic manipulation in animal models to observe changes in NSC behavior and stroke outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery for stroke survivors by harnessing the therapeutic potential of neural stem cells.
How similar studies have gone: While the specific role of LRP1 in NSC biology is largely unstudied, previous research has shown that manipulating cell signaling pathways can lead to significant improvements in recovery from brain injuries.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Sayre, Naomi Ledene — University of Texas Hlth Science Center
- Study coordinator: Sayre, Naomi Ledene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.