Investigating how LRP1 affects neural stem cells after a stroke
Official title: LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response
Funded at University of Texas Hlth Science Center · NIH-10900735 · Data updated 2026-11-12
This study is looking at how a specific protein called LRP1 affects the movement and healing abilities of brain cells after a stroke, with the goal of finding better ways to help people recover from such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $384,458 |
| NIH project number | 5R01NS132778-02 |
| Project ID | NIH-10900735 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced an ischemic stroke and are seeking innovative therapies to aid their recovery.
✕Less likely to help
Patients who have not suffered a stroke or those with chronic neurological conditions unrelated to stroke may not benefit from this research.
What this research studies
This research explores the role of LRP1, a receptor that influences cell signaling, in the behavior of neural stem cells (NSCs) following an ischemic stroke. The study aims to understand how LRP1 affects NSC migration to brain injury sites and their ability to promote recovery. By examining the effects of LRP1 on NSC function, the researchers hope to uncover new insights that could enhance the therapeutic use of these cells in stroke recovery. The methodology involves genetic manipulation in animal models to observe changes in NSC behavior and recovery outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for stroke survivors, potentially enhancing recovery and reducing long-term disability.
How similar studies have gone: While the specific role of LRP1 in NSC biology is largely unstudied, previous research has shown promise in using neural stem cells for stroke recovery, indicating potential for success in this novel approach.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Sayre, Naomi Ledene — University of Texas Hlth Science Center
- Study coordinator: Sayre, Naomi Ledene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.