Investigating how low-density lipoprotein affects inflammation
Novel Function of Native Low-Density Lipoprotein in Inflammation
This study is looking at how a type of cholesterol called LDL affects inflammation in the body, which can be connected to heart problems and digestive issues, to help find better treatments for people dealing with these health challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10892821 on NIH RePORTER |
What this research studies
This research explores the role of native low-density lipoprotein (LDL) in the inflammatory response, which is linked to various diseases such as cardiovascular disease and inflammatory bowel disease. The study uses animal models to examine how high levels of LDL influence inflammation and disease susceptibility. By understanding the mechanisms through which LDL interacts with immune cells, the research aims to uncover new insights into its contribution to inflammatory diseases. This could lead to better-targeted therapies for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to inflammation, such as cardiovascular disease or inflammatory bowel disease.
Not a fit: Patients who do not have inflammatory conditions or those with low LDL levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate inflammation-related diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding lipid interactions in inflammation can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zaki, Hasan — Ut Southwestern Medical Center
- Study coordinator: Zaki, Hasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.