Investigating how loss of the Y chromosome in blood cells affects aging
Official title: The Role of Hematopoietic Loss of Y Chromosome on Aging Phenotypes
Funded at Seattle Children's Hospital · NIH-10643778 · Data updated 2026-11-12
This study is looking at how a common genetic change in blood cells, which happens more often as men get older, might be linked to health problems like heart failure, cancer, and dementia, and it aims to help us understand how this change affects aging and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $186,408 |
| NIH project number | 1K22AG081323-01 |
| Project ID | NIH-10643778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older men, particularly those over the age of 70, who may be experiencing age-related health issues.
✕Less likely to help
Patients who are not male or those under the age of 70 may not receive direct benefits from this research.
What this research studies
This research explores the impact of mosaic loss of the Y chromosome (mLOY) in blood cells on aging and related health issues. It focuses on how this genetic change, which becomes more common as men age, may contribute to conditions like heart failure, cancer, and dementia. By using advanced techniques such as single-cell RNA sequencing and mouse models, the study aims to uncover the mechanisms linking mLOY to various age-related diseases. Patients may be involved in understanding how these genetic factors influence their health as they age.
Why it matters
Potential benefit: If successful, this research could lead to new insights into aging and potential interventions for age-related diseases in men.
How similar studies have gone: Previous research has shown promising results in understanding the implications of genetic mutations on aging, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Chavkin, Nicholas W — Seattle Children's Hospital
- Study coordinator: Chavkin, Nicholas W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.