Investigating how long non-coding RNAs help activate genes
Official title: Structural and Functional Studies of lncRNAs in Gene Activation
Funded at Drexel University · NIH-11076893 · Data updated 2026-11-12
This study is looking at how certain molecules called long non-coding RNAs help turn on genes, which could be important for understanding and treating cancers, and it aims to find new ways to help patients by learning how these molecules affect disease and treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $20,745 |
| NIH project number | 3R01GM149780-02S1 |
| Project ID | NIH-11076893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers where lncRNA dysregulation is implicated.
✕Less likely to help
Patients with conditions unrelated to lncRNA dysregulation or those not diagnosed with cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of long non-coding RNAs (lncRNAs) in the activation of genes, particularly how they interact with the SWI/SNF complex, which is important for gene regulation and is known to be involved in various cancers. By exploring the mechanisms of lncRNAs, the research aims to uncover their potential as biomarkers and therapeutic targets for diseases. The study will utilize advanced sequencing technologies and biochemical methods to analyze the interactions between lncRNAs and gene activation processes. Patients may benefit from insights gained into how these molecules influence disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cancers by targeting lncRNAs.
How similar studies have gone: Other research has shown promising results in understanding the role of lncRNAs in gene regulation, indicating that this approach has potential for success.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Somarowthu, Srinivas — Drexel University
- Study coordinator: Somarowthu, Srinivas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.