Investigating how long non-coding RNAs affect the sense of smell
Official title: A new dimension to the olfactory system: long non-coding (lnc)RNAs and a lncRNA-encoded micropeptide
Funded at Yale University · NIH-11026389 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in our genes affect our sense of smell, using fruit flies to learn more about how our noses adapt to different situations, which could help us understand more about how we smell and how it impacts our behavior.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 5, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $121,722 |
| NIH project number | 5K99DC021743-02 |
| Project ID | NIH-11026389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with olfactory dysfunction or those interested in the biological mechanisms of smell.
✕Less likely to help
Patients with conditions unrelated to olfactory function or those who do not experience any olfactory issues may not benefit from this research.
What this research studies
This research explores the role of long non-coding RNAs (lncRNAs) and their encoded micropeptides in the olfactory system, particularly focusing on how they influence olfactory receptor neurons. By using the fruit fly as a model organism, the study aims to uncover the mechanisms behind olfactory plasticity, which is the ability of the olfactory system to adapt based on internal states. The research employs genetic tools to manipulate and observe the effects of lncRNAs on sensory neuronal activity, providing insights into their functions in the nervous system. This could lead to a better understanding of how olfaction works and its implications for behavior and survival.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of olfactory functions and potentially lead to new treatments for olfactory disorders.
How similar studies have gone: While the role of lncRNAs in other biological processes has been studied, the specific investigation of their impact on olfaction is relatively novel and has not been extensively tested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Talross, Gaëlle J.s. — Yale University
- Study coordinator: Talross, Gaëlle J.s.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.