Investigating how long non-coding RNAs affect the formation of exosomes
Role of Long Non-Coding RNAs in Exosome Biogenesis
This study is looking at how certain molecules called long non-coding RNAs help cells create tiny bubbles called exosomes, which play a big role in cell communication and can affect diseases like cancer, especially when cells are under stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11135842 on NIH RePORTER |
What this research studies
This research explores the role of long non-coding RNAs (lncRNAs) in the biogenesis of exosomes, which are tiny vesicles released by cells that facilitate communication and transport of molecules. The study aims to understand how lncRNAs regulate the processes involved in exosome formation, including their docking and cargo sorting, particularly under stress conditions like hypoxia. By examining these mechanisms, the research seeks to uncover new insights into how exosomes contribute to various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may involve exosome dysfunction, such as cancer or other diseases characterized by cellular stress.
Not a fit: Patients with conditions unrelated to exosome biology or those not experiencing cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic and therapeutic strategies targeting exosome-related pathways in diseases.
How similar studies have performed: While the role of exosomes in disease is a growing field, the specific investigation of lncRNAs in exosome biogenesis is relatively novel and has not been extensively tested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Momen Heravi, Fatemeh — University of California, San Francisco
- Study coordinator: Momen Heravi, Fatemeh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.