Investigating how long non-coding RNAs affect HIV replication and disease outcomes
Role of cellular long non-coding RNAs in HIV replication and disease outcome
This study is looking at how certain molecules in our cells, called long non-coding RNAs, affect HIV infection and the immune response, especially in people who can naturally control the virus, to find new ways to treat HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10886530 on NIH RePORTER |
What this research studies
This research explores the role of long non-coding RNAs (lncRNAs) in the context of HIV infection. It aims to understand how these lncRNAs influence the replication of the virus and the immune response in patients, particularly focusing on a unique group of individuals known as elite controllers who can naturally suppress HIV. By analyzing changes in lncRNA expression in HIV-infected cells, the study seeks to uncover potential mechanisms that could lead to new therapeutic strategies for HIV treatment. The methodology includes advanced techniques like CRISPR to manipulate lncRNA expression and assess their functional impact.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those who are classified as elite controllers.
Not a fit: Patients who are not infected with HIV or those who do not have a significant immune response to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help control or even cure HIV infection.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in other diseases, suggesting potential for success in this novel approach to HIV.
Where this research is happening
San Antonio, United States
- Texas Biomedical Research Institute — San Antonio, United States (Active)
Researchers
- Principal investigator: Kulkarni, Smita — Texas Biomedical Research Institute
- Study coordinator: Kulkarni, Smita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.