Investigating how long non-coding RNAs affect blood vessel growth after a stroke
Long Non-Coding RNAs and Cerebral Angiogenesis in Ischemic Stroke
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10778598
This study is looking at how certain molecules in our body, called lncRNAs, help create new blood vessels after a stroke, which could lead to better recovery for stroke patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10778598 on ClinicalTrials.gov |
What this research studies
This research explores the role of long non-coding RNAs (lncRNAs) in promoting blood vessel growth following ischemic stroke, which is crucial for improving blood flow and neurological recovery. The study focuses on understanding how lncRNAs influence the expression of genes and proteins involved in angiogenesis, the process of new blood vessel formation. By examining the mechanisms of lncRNAs, particularly one called Malat1, the research aims to identify potential therapeutic targets that could enhance recovery in stroke patients. The approach includes using advanced techniques like RNA sequencing to analyze changes in lncRNA expression after stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced an ischemic stroke and are seeking potential new therapies to aid their recovery.
Not a fit: Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery outcomes for stroke patients by enhancing blood flow to affected areas of the brain.
How similar studies have performed: Previous research has shown promising results in targeting lncRNAs for therapeutic purposes in various conditions, suggesting that this approach may also be effective in stroke recovery.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, DANDAN — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SUN, DANDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer