Investigating how long-chain acyl-carnitines affect heart function in obesity and heart failure.
Official title: Role of Extracellular Long-Chain Acyl-carnitines in the Normal and Stressed Heart
Funded at Johns Hopkins University · NIH-10995420 · Data updated 2026-11-12
This study is looking at how certain fats in the body affect heart function in people with heart failure who are also obese, to see if understanding this can help find better ways to treat their condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $32,974 |
| NIH project number | 1F31HL176029-01 |
| Project ID | NIH-10995420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing heart failure, especially those with obesity.
✕Less likely to help
Patients without heart failure or those who are not obese may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the role of long-chain acyl-carnitines in the heart, particularly in patients with heart failure (HF) who are also obese. The study aims to determine whether these compounds can be effectively utilized by heart cells for energy, especially when their uptake may be impaired in HF. By examining the transport mechanisms and metabolic pathways involved, the research seeks to uncover how obesity impacts heart metabolism and function. Patients may benefit from insights that could lead to new treatment strategies for managing heart failure in the context of obesity.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with heart failure, particularly those who are obese.
How similar studies have gone: Previous research has indicated that understanding metabolic pathways in heart failure can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Mulligan, Abigail S. — Johns Hopkins University
- Study coordinator: Mulligan, Abigail S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.