Investigating how loneliness affects cognitive decline and dementia risk in older adults

The role of loneliness in cognitive decline and risk for dementia

NIH-funded research Pennsylvania State University, the · NIH-10825593

This study is looking at how feeling lonely might affect memory and thinking skills in older adults, especially those with Alzheimer's, and it’s for older folks who want to help us understand this important connection better.

Quick facts

Grant typeR03 grant
Study typeNIH-funded research
Funding institutionPennsylvania State University, the NIH-funded
Lab location1 site (University Park, United States)
Project IDNIH-10825593 on NIH RePORTER

What this research studies

This research explores the connection between loneliness and cognitive decline in older adults, particularly focusing on Alzheimer's disease. By examining data over time, the study aims to determine whether loneliness contributes to cognitive decline or is a result of it. Participants will be part of the Einstein Aging Study, which includes diverse older adults who will undergo multiple assessments to gather comprehensive data on their cognitive health and experiences of loneliness. The research will also investigate the biological mechanisms that may link loneliness to an increased risk of dementia.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 70 and above who may experience feelings of loneliness.

Not a fit: Patients who are younger than 70 or do not experience loneliness may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and dementia by addressing loneliness in older adults.

How similar studies have performed: Previous studies have indicated a correlation between loneliness and cognitive decline, but this research aims to provide novel insights through a longitudinal approach.

Where this research is happening

University Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementia
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.