Investigating how liver inflammation affects brain health in older adults
The role of hepatocyte necroptosis and inflammation in liver-brain crosstalk in aging
This study is looking at how liver inflammation might be linked to memory and thinking problems in older adults, and it hopes to find ways to improve brain health by targeting a specific process that causes cell death in the liver.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10980163 on NIH RePORTER |
What this research studies
This research explores the connection between liver inflammation and cognitive decline in aging individuals. It focuses on a specific cell death process called necroptosis, which may contribute to inflammation in the liver and subsequently affect brain function. By studying this relationship, the research aims to identify potential pathways that could be targeted to improve cognitive health in older adults. The approach includes both animal models and potential pharmacological interventions to reduce liver inflammation and its effects on the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are experiencing cognitive decline or have chronic liver conditions.
Not a fit: Patients who are younger than 65 or do not have any cognitive impairments or liver diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and overall brain health in older adults suffering from liver-related inflammation.
How similar studies have performed: Previous research has indicated a link between liver health and cognitive function, suggesting that this approach may yield valuable insights, although the specific focus on necroptosis in this context is relatively novel.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Sathyaseelan, Deepa — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Sathyaseelan, Deepa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.