Investigating how liver cells regenerate after injury
The role of liver progenitor cells in liver regeneration
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11014052
This study is looking at how certain cells in the liver can help it heal after serious damage, using zebrafish to learn how these cells change and grow into new liver cells, which could eventually lead to better treatments for liver diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11014052 on ClinicalTrials.gov |
What this research studies
This research explores the role of liver progenitor cells in the regeneration of the liver, particularly after severe damage. By using a zebrafish model, the study aims to understand how biliary epithelial cells can transform into liver cells following significant liver injury. The researchers will analyze cellular changes and signaling pathways involved in this process, providing insights into liver regeneration mechanisms. This work could lead to new therapeutic strategies for liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from acute or chronic liver diseases.
Not a fit: Patients with stable liver function and no history of liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver diseases and enhance recovery strategies for patients with liver failure.
How similar studies have performed: Previous research has shown promising results in understanding liver regeneration mechanisms, but this specific approach using zebrafish is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOESSLING, WOLFRAM — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: GOESSLING, WOLFRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.