Investigating how liver cells heal after injury
Official title: Milk fat globule-EGF factor 8 and hepatocyte apoptosis-induced liver wound healing response
Funded at Jesse Brown VA Medical Center · NIH-10856910 · Data updated 2026-11-12
This study is looking at how the liver heals after injury, especially in older adults, to find ways to help people recover better from liver problems like cirrhosis and liver cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 30, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006085-02 |
| Project ID | NIH-10856910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who are experiencing liver injuries or related conditions.
✕Less likely to help
Patients with liver injuries not associated with apoptosis or those under the age of 65 may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind liver healing after injury, particularly in older adults. It utilizes a specialized mouse model to study how liver cells, known as hepatocytes, respond to apoptosis (cell death) and the subsequent inflammatory processes that occur. By identifying the molecules that promote liver regeneration, the research aims to uncover new strategies to enhance recovery from liver injuries, which can lead to chronic diseases like cirrhosis and liver cancer. The findings could provide insights into better treatment options for patients suffering from liver-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver injuries, potentially reducing the risk of chronic liver disease and enhancing recovery for affected patients.
How similar studies have gone: Previous studies have shown success in understanding liver healing mechanisms, but this specific approach using the 3xTg-iHAP mouse model is relatively novel.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Tan, Xiao-Di — Jesse Brown VA Medical Center
- Study coordinator: Tan, Xiao-Di
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.