Investigating how lipids influence the function of a specific receptor in cell signaling.
Official title: Supplemental Postdoc: Lipid dependent GPCR signaling: Thermodynamics and mechanisms
Funded at University of Delaware · NIH-11098166 · Data updated 2026-11-12
This study is looking at how fats in cell membranes influence a specific type of receptor that helps control many important functions in our bodies, which could help improve treatments for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | January 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $24,294 |
| NIH project number | 3R35GM153273-01S1 |
| Project ID | NIH-11098166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions influenced by GPCR signaling, such as cardiovascular diseases or neurological disorders.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling may not receive any benefit from this research.
What this research studies
This research explores the role of lipids in regulating G-protein coupled receptors (GPCRs), which are crucial for many cellular functions and pharmaceutical targets. By examining the A2A adenosine receptor, the study aims to understand how different lipid compositions in cell membranes affect receptor activation and signaling. The approach involves computational simulations and biological models to quantify the interactions between lipids and GPCRs, providing insights into their mechanisms of action. This could lead to a better understanding of GPCR function in various physiological contexts.
Why it matters
Potential benefit: If successful, this research could enhance the development of targeted therapies for conditions related to GPCR dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding GPCR mechanisms through lipid interactions, indicating that this approach has potential for success.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Lyman, Edward Ray — University of Delaware
- Study coordinator: Lyman, Edward Ray
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.