Investigating how lipids affect cell function and diseases.
Lipidic drivers of organelle function and dysregulation
This study is looking at how fats in our cells can affect diseases like type 2 diabetes and brain disorders, and it aims to find out how changing these fats can help improve how our cells work, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10895328 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of lipids, which are essential components of cell membranes, in various diseases such as type 2 diabetes and neurodegenerative disorders. By using genetic and chemical tools, the researchers aim to manipulate and observe how changes in lipid composition impact cellular processes, particularly in mitochondria. The study will involve engineering lipid compositions in both yeast and mammalian cell lines to explore how these changes affect cellular metabolism and function. Patients may benefit from insights gained about lipid-related mechanisms that contribute to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are affected by adult-onset diabetes or neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to lipid metabolism or those under 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting lipid metabolism to improve outcomes for patients with metabolic and neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding lipid functions in cellular processes, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Budin, Itay — University of California, San Diego
- Study coordinator: Budin, Itay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.