Investigating how lipids affect brain aging and Alzheimer's disease
Official title: Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease
Funded at Duke University · NIH-11076678 · Data updated 2026-11-12
This study is looking at how fats in the body affect brain aging and Alzheimer's disease, hoping to find clues that could help develop new treatments and improve our understanding of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $546,999 |
| NIH project number | 5R01AG081322-03 |
| Project ID | NIH-11076678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-age-related cognitive impairments or those not affected by Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the role of lipids in brain aging and Alzheimer's disease (AD) by utilizing advanced lipidomic techniques. The study aims to understand how changes in lipid metabolism contribute to the progression of AD and related dementias. By analyzing lipid profiles from various cohorts, the research seeks to identify metabolic alterations that occur as the disease progresses, potentially linking these changes to genetic factors. The findings could lead to new targets for drug development and improved understanding of AD mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease.
How similar studies have gone: Previous research in lipidomics has shown promise in understanding Alzheimer's disease, indicating that this approach may yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — Duke University
- Study coordinator: Kaddurah-Daouk, Rima F
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.