Investigating how lipid transport affects heart function in heart failure
Transendothelial transport and CD36 in the dysregulated lipid trafficking of failing hearts
This study is looking at how heart failure affects the way heart cells get important fats they need to work properly, using mice to help understand the problem better, with the hope of finding new ways to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10983342 on NIH RePORTER |
What this research studies
This research focuses on understanding how the delivery and uptake of long chain fatty acids (LCFAs) by heart cells are disrupted in heart failure. Using a mouse model that mimics human heart failure, the study examines the role of endothelial cells in delivering LCFAs to cardiac muscle cells and how this affects heart metabolism and function. The researchers will analyze the mechanisms behind lipid metabolism changes and the impact of specific proteins involved in this process. This work aims to uncover potential therapeutic targets to improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or related cardiac disorders.
Not a fit: Patients without heart failure or those with non-cardiac related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and metabolism in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism in heart failure, indicating that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Lewandowski, E Douglas — Ohio State University
- Study coordinator: Lewandowski, E Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.