Investigating how lipid signaling affects pain pathways in the brain
Lipid signaling in supraspinal pain pathways
This study is looking at how certain brain cells in the central amygdala affect how we feel and manage pain, and it’s testing whether a specific molecule called S1P can help reduce pain in conditions like inflammation and nerve damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10819209 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific neurons in the central amygdala (CeA) influence pain perception and modulation. By using advanced techniques such as transgenic mouse models and electrophysiology, the researchers aim to explore how lipid signaling, particularly through the receptor for sphingosine-1-phosphate (S1P), can alter the excitability of these neurons. The study will assess the potential analgesic effects of S1P in models of both inflammatory and neuropathic pain, providing insights into the neurochemical mechanisms underlying chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions, particularly those related to inflammation or nerve injury.
Not a fit: Patients with acute pain not related to chronic conditions or those without a neurological component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain by targeting specific signaling pathways in the brain.
How similar studies have performed: Previous research has shown promising results in targeting lipid signaling pathways for pain modulation, suggesting potential for success in this approach.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Sheets, Patrick L — Indiana University Indianapolis
- Study coordinator: Sheets, Patrick L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.