Investigating how lipid signaling affects Alzheimer's disease
Soluble epoxide hydrolase-regulated lipid signaling in Alzheimer’s disease
This study is looking at how certain fats in the body can help reduce inflammation and protect the brain in people with Alzheimer's disease, and it hopes to find new ways to improve brain health by blocking an enzyme that breaks down these helpful fats.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11059882 on NIH RePORTER |
What this research studies
This research focuses on the role of lipid mediators, specifically epoxy fatty acids, in regulating inflammation and neuroprotection in Alzheimer's disease. By inhibiting soluble epoxide hydrolase (sEH), the study aims to enhance the beneficial effects of these lipids, potentially leading to improved brain function. The approach involves both laboratory models and analysis of how these lipid signals interact within the brain and liver. Patients may benefit from insights into new therapeutic strategies targeting lipid signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Alzheimer's disease and improve cognitive function.
How similar studies have performed: Previous research has shown promising results in using similar lipid signaling approaches to mitigate Alzheimer's disease symptoms.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Maezawa, Izumi — University of California at Davis
- Study coordinator: Maezawa, Izumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.