Investigating how lipid-rich macrophages affect prostate cancer therapy
Official title: Lipid-Rich Macrophages at the Tumor-Adipose Interface: A New Target for Locally-Invasive Prostate Cancer Therapy
Funded at Endeavor Health Clinical Operations · NIH-10943514 · Data updated 2026-11-12
This study is looking at how certain fat-filled immune cells around the prostate might affect prostate cancer growth, with the hope of finding new ways to treat the disease that are better suited to individual patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endeavor Health Clinical Operations NIH-funded |
| Lab location | 1 site (Evanston, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $433,157 |
| NIH project number | 1R21CA291898-01 |
| Project ID | NIH-10943514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with locally-invasive prostate cancer who may benefit from targeted therapies.
✕Less likely to help
Patients with advanced metastatic prostate cancer or those not diagnosed with prostate cancer may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of lipid-rich macrophages in the tumor microenvironment of prostate cancer. It examines how these macrophages interact with peri-prostatic fat, which is a fatty tissue surrounding the prostate, and how this interaction may influence tumor growth and progression. By studying the metabolic changes in these macrophages and their impact on tumor cells, the research aims to identify new therapeutic targets for locally-invasive prostate cancer treatment. Patients may benefit from insights that could lead to more effective therapies tailored to their specific tumor environments.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve treatment outcomes for prostate cancer patients.
How similar studies have gone: While the specific approach of targeting lipid-rich macrophages in prostate cancer is relatively novel, similar studies in other cancers have shown promising results.
Where this research is happening
-
Endeavor Health Clinical Operations
Evanston, United States Active
Researchers
- Principal investigator: Hayward, Simon W — Endeavor Health Clinical Operations
- Study coordinator: Hayward, Simon W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.