Investigating how lipid-rich macrophages affect prostate cancer therapy
Lipid-Rich Macrophages at the Tumor-Adipose Interface: A New Target for Locally-Invasive Prostate Cancer Therapy
['FUNDING_R21'] · ENDEAVOR HEALTH CLINICAL OPERATIONS · NIH-10943514
This study is looking at how certain fat-filled immune cells around the prostate might affect prostate cancer growth, with the hope of finding new ways to treat the disease that are better suited to individual patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ENDEAVOR HEALTH CLINICAL OPERATIONS (nih funded) |
| Locations | 1 site (EVANSTON, UNITED STATES) |
| Trial ID | NIH-10943514 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of lipid-rich macrophages in the tumor microenvironment of prostate cancer. It examines how these macrophages interact with peri-prostatic fat, which is a fatty tissue surrounding the prostate, and how this interaction may influence tumor growth and progression. By studying the metabolic changes in these macrophages and their impact on tumor cells, the research aims to identify new therapeutic targets for locally-invasive prostate cancer treatment. Patients may benefit from insights that could lead to more effective therapies tailored to their specific tumor environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with locally-invasive prostate cancer who may benefit from targeted therapies.
Not a fit: Patients with advanced metastatic prostate cancer or those not diagnosed with prostate cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve treatment outcomes for prostate cancer patients.
How similar studies have performed: While the specific approach of targeting lipid-rich macrophages in prostate cancer is relatively novel, similar studies in other cancers have shown promising results.
Where this research is happening
EVANSTON, UNITED STATES
- ENDEAVOR HEALTH CLINICAL OPERATIONS — EVANSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAYWARD, SIMON W — ENDEAVOR HEALTH CLINICAL OPERATIONS
- Study coordinator: HAYWARD, SIMON W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.