Investigating how lipid peroxidation affects cell membranes and contributes to diseases
Membrane reconstitution approach for the investigation of lipid peroxidation mechanisms and its pathological effects
['FUNDING_OTHER'] · COLORADO STATE UNIVERSITY · NIH-10908401
This study is looking at how certain chemical changes in our cells, which can happen as we age and are linked to diseases like Alzheimer's and cancer, affect cell health, and the researchers want to find a better way to measure these changes to help us understand and possibly treat these conditions better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-10908401 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the chemical processes behind lipid peroxidation in cell membranes, which is linked to aging and various diseases like Alzheimer's and cancer. The researchers aim to develop a new method to measure lipid peroxidation accurately in a biological context, overcoming limitations of previous studies. By using advanced microscopy techniques, they will explore how lipid peroxidation leads to cell death through a process called ferroptosis. This could provide insights into the underlying mechanisms of age-related diseases and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals at risk for age-related diseases, particularly those with a family history of Alzheimer's or other neurodegenerative conditions.
Not a fit: Patients who are not experiencing age-related diseases or do not have risk factors for such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for age-related diseases such as Alzheimer's and cancer.
How similar studies have performed: While lipid peroxidation has been studied in various contexts, this specific approach using membrane-based assays and fluorescence microscopy is relatively novel.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHUNG, JEAN — COLORADO STATE UNIVERSITY
- Study coordinator: CHUNG, JEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease