Investigating how lipid metabolism affects tumor growth
Official title: Exploring the interaction of lipid metabolism with the hexosamine pathway and tumor growth
Funded at Ohio State University · NIH-11003700 · Data updated 2026-11-12
This study is looking at how cancer cells use fats to grow and survive, and it aims to find new ways to target these processes for better cancer treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 22, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $184,078 |
| NIH project number | 5R21CA280452-02 |
| Project ID | NIH-11003700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of cancer who may benefit from novel metabolic-targeted therapies.
✕Less likely to help
Patients with non-cancerous conditions or those whose tumors do not exhibit metabolic reprogramming may not benefit from this research.
What this research studies
This research explores the relationship between lipid metabolism and tumor growth, focusing on how lipid droplets in cancer cells adapt to their environment. By using advanced techniques like CRISPR engineering, the researchers aim to identify new regulators that influence lipid droplet turnover, which is crucial for cancer cell survival and proliferation. The study examines the hexosamine biosynthetic pathway, which is linked to cancer metabolism and may reveal new targets for anti-cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that disrupt the metabolic processes of tumors, potentially improving cancer therapy outcomes.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Papandreou, Ioanna — Ohio State University
- Study coordinator: Papandreou, Ioanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.