Investigating how lipid metabolism affects inflammation and atherosclerosis
Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation
['FUNDING_R01'] · CLEVELAND STATE UNIVERSITY · NIH-10878045
This study is looking at how certain fats in the body affect heart health and inflammation, especially in people with atherosclerosis, to find new ways to improve treatments for heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND STATE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10878045 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of phosphatidylinositol metabolism and trafficking in the context of atherosclerosis and inflammation. It examines how dysfunctional immune responses to modified lipids and cholesterol contribute to chronic inflammation, which is a major factor in cardiovascular diseases. By exploring the mechanisms involving ATP8b1, a protein linked to cholesterol metabolism, the research aims to uncover new insights into how these processes affect heart health. Patients may benefit from advancements in treatment strategies that arise from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis or those at high risk for cardiovascular diseases due to metabolic disorders.
Not a fit: Patients without any cardiovascular risk factors or those not affected by metabolic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Other research has shown promising results in understanding lipid metabolism and inflammation, indicating that this approach could yield significant insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND STATE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GULSHAN, KAILASH — CLEVELAND STATE UNIVERSITY
- Study coordinator: GULSHAN, KAILASH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.