Investigating how lipid metabolism affects inflammation and atherosclerosis
Official title: Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation
Funded at Cleveland State University · NIH-10878045 · Data updated 2026-11-12
This study is looking at how certain fats in the body affect heart health and inflammation, especially in people with atherosclerosis, to find new ways to improve treatments for heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 1, 2020 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $540,777 |
| NIH project number | 2R01HL148158-06 |
| Project ID | NIH-10878045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with atherosclerosis or those at high risk for cardiovascular diseases due to metabolic disorders.
✕Less likely to help
Patients without any cardiovascular risk factors or those not affected by metabolic diseases may not benefit from this research.
What this research studies
This research focuses on understanding the role of phosphatidylinositol metabolism and trafficking in the context of atherosclerosis and inflammation. It examines how dysfunctional immune responses to modified lipids and cholesterol contribute to chronic inflammation, which is a major factor in cardiovascular diseases. By exploring the mechanisms involving ATP8b1, a protein linked to cholesterol metabolism, the research aims to uncover new insights into how these processes affect heart health. Patients may benefit from advancements in treatment strategies that arise from this understanding.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Other research has shown promising results in understanding lipid metabolism and inflammation, indicating that this approach could yield significant insights.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Gulshan, Kailash — Cleveland State University
- Study coordinator: Gulshan, Kailash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.