Investigating how lipid metabolism affects cancer cell death to find new treatment targets
Official title: Spatial metabolomics with subcellular resolution to identify therapeutic targets
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11070399 · Data updated 2026-11-12
This study is looking at how certain fats in our cells can affect the way cancer cells die, especially those that don’t respond well to treatment, to help make them more sensitive to chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 7, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $375,000 |
| NIH project number | 5R35GM150564-03 |
| Project ID | NIH-11070399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with drug-resistant cancers or those at risk of cancer recurrence.
✕Less likely to help
Patients with early-stage cancers that are easily treatable with current therapies may not benefit from this research.
What this research studies
This research focuses on understanding how certain lipids in cells can influence cell death, particularly in cancer cells that resist treatment. By exploring a specific type of cell death called ferroptosis, the researchers aim to find ways to make drug-resistant cancer cells more susceptible to chemotherapy. The study will utilize advanced techniques to analyze lipid distribution and modifications at a single-cell level, both in laboratory cultures and in living models. This approach could lead to new therapeutic targets for various diseases linked to lipid metabolism, including cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by overcoming drug resistance in cancer cells.
How similar studies have gone: Other research has shown promise in targeting lipid metabolism for cancer treatment, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Gartia, Manas Ranjan — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Gartia, Manas Ranjan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.