Investigating how lipid mediators affect kidney function and blood pressure regulation
Official title: BLR&D Research Career Scientist Award Application
Funded at VA Salt Lake City Healthcare System · NIH-11103171 · Data updated 2026-11-12
This study is looking at how certain substances in the body, called prostaglandins, affect kidney function and blood pressure, with the goal of finding better ways to help people with chronic kidney disease and high blood pressure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5IK6BX005223-06 |
| Project ID | NIH-11103171 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic kidney disease or hypertension.
✕Less likely to help
Patients with acute kidney injury or those not experiencing issues with blood pressure regulation may not benefit from this research.
What this research studies
This research focuses on understanding the role of lipid-derived mediators, particularly prostaglandins, in regulating kidney function and blood pressure. The approach involves studying the interactions between these mediators and the renin-angiotensin system, which is crucial for maintaining blood pressure and fluid balance. By examining how these pathways influence kidney health and disease, the research aims to uncover mechanisms that could lead to better management of conditions like chronic kidney disease and hypertension.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for managing blood pressure and kidney health in patients with chronic conditions.
How similar studies have gone: Previous research has shown promising results in understanding lipid mediators' roles in kidney function, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Yang, Tianxin — VA Salt Lake City Healthcare System
- Study coordinator: Yang, Tianxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.