Investigating how lipid balance and mitochondrial health affect LAM disease and treatment
Official title: Lipid homeostasis and mitochondrial fitness in LAM pathogenesis and therapy
Funded at Brigham and Women's Hospital · NIH-10930187 · Data updated 2026-11-12
This study is looking at how problems with fat processing and energy production in cells might make lymphangioleiomyomatosis (LAM) worse, with the goal of finding new ways to help women with this rare lung disease feel better and slow down its progress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $434,868 |
| NIH project number | 1R56HL163284-01A1 |
| Project ID | NIH-10930187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with lymphangioleiomyomatosis (LAM).
✕Less likely to help
Patients with other lung diseases or those not diagnosed with LAM may not receive any benefit from this research.
What this research studies
This research focuses on lymphangioleiomyomatosis (LAM), a rare disease affecting women that leads to severe lung damage. The study aims to understand how disruptions in lipid metabolism and mitochondrial function contribute to the progression of LAM. By exploring the role of specific enzymes and metabolic pathways, the researchers hope to identify new therapeutic strategies that could enhance treatment responses and slow disease progression. Patients may benefit from insights gained into their condition and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for LAM, enhancing treatment effectiveness and patient outcomes.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in similar conditions, suggesting potential for success in this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Priolo, Carmen — Brigham and Women's Hospital
- Study coordinator: Priolo, Carmen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.