Investigating how light-sensitive proteins affect brain activity and vision.
Structure/Function of Channelrhodopsins and Related Retinylidene Proteins
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11041036
This study is looking at special proteins that react to light to help scientists learn how to control brain activity, which could lead to new ways to treat conditions like blindness and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11041036 on ClinicalTrials.gov |
What this research studies
This research explores the structure and function of channelrhodopsins, which are proteins that respond to light and play a crucial role in controlling electrical signals in cells. By studying these proteins, the research aims to understand how they can be used to manipulate neuronal activity through light, a technique known as optogenetics. This approach has the potential to advance our understanding of brain circuitry and could lead to new treatments for conditions like blindness and cardiac disorders. The research involves detailed molecular analysis and experimentation with these proteins to uncover their mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with vision impairments or cardiac conditions who may benefit from new therapeutic approaches.
Not a fit: Patients with conditions unrelated to neuronal activity or cardiac function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for restoring vision in blind individuals and improving treatments for cardiac diseases.
How similar studies have performed: Previous research has successfully utilized similar optogenetic approaches to manipulate neuronal activity, indicating a promising avenue for further exploration.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPUDICH, JOHN LEE — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: SPUDICH, JOHN LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders