Investigating how light affects corneal pain and sensitivity
Molecular, cellular, anatomical and neurobiological investigation of melanopsin-expressing corneal innervation, and its role in pain and photophobia
['FUNDING_R01'] · UNIVERSITY OF HOUSTON · NIH-11192986
This study is looking at how certain nerve cells in the eye respond to light and affect pain, especially for people dealing with corneal injuries or dry eye, to help find better ways to treat their discomfort.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11192986 on ClinicalTrials.gov |
What this research studies
This research explores the role of specific sensory neurons in the cornea that respond to light and contribute to pain and sensitivity. It aims to understand how these neurons, which express a protein called melanopsin, are involved in conditions like corneal injury and dry eye disease. By studying these mechanisms, the research seeks to uncover new insights into how light can influence pain perception, potentially leading to better treatments for patients suffering from debilitating corneal pain. The approach includes using disease models to assess the function of these neurons in both normal and sensitized states.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from corneal pain, dry eye disease, or conditions that cause light sensitivity.
Not a fit: Patients with corneal pain not related to melanopsin-expressing neurons or those without any corneal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients experiencing chronic corneal pain and light sensitivity.
How similar studies have performed: While the specific investigation of melanopsin-expressing neurons in corneal pain is relatively novel, there is accumulating evidence suggesting that light can influence pain perception, indicating potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATYNIA, ANNA — UNIVERSITY OF HOUSTON
- Study coordinator: MATYNIA, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.