Investigating how leukemia affects blood vessel changes in bone marrow
Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?
This study is looking at how leukemia stem cells change the blood vessels in the bone marrow to help them grow and resist treatment, and it aims to find new ways to target these changes to improve outcomes for people with acute myeloid leukemia (AML).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10817034 on NIH RePORTER |
What this research studies
This research focuses on understanding how leukemia stem cells (LSCs) alter the blood vessels in the bone marrow, which supports their growth and resistance to treatment. By examining the role of specific molecules, such as microRNAs, the study aims to uncover the mechanisms behind these changes. The goal is to identify potential therapeutic targets that could help eliminate LSCs and improve treatment outcomes for patients with acute myeloid leukemia (AML). Patients may be involved in trials that test new approaches to counteract these vascular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who may benefit from novel therapeutic strategies.
Not a fit: Patients with other types of leukemia or those who are not currently undergoing treatment for AML may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target and eliminate leukemia stem cells, improving survival rates for patients with AML.
How similar studies have performed: Previous research has shown promising results in targeting similar mechanisms in leukemia, suggesting that this approach could be effective.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Marcucci, Guido — Beckman Research Institute/city of Hope
- Study coordinator: Marcucci, Guido
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.