Investigating how leucine affects brain function in older adults with depression
Leucine as a Probe of Kynurenine-Induced Glutamate and Neural Circuit Dysfunction in Midlife Depression
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11164827
This study is looking at how a specific process in the body might connect inflammation and brain changes to depression in people aged 65 and older, and it’s testing whether an amino acid called leucine can help improve mood by protecting the brain from harmful substances.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11164827 on ClinicalTrials.gov |
What this research studies
This research explores the role of the kynurenine pathway in linking inflammation and glutamate imbalances to brain aging and major depression in individuals aged 65 and older. It focuses on how leucine, an amino acid, may block the entry of harmful kynurenine metabolites into the brain, potentially alleviating depressive symptoms. The study involves both preclinical and human data to understand the mechanisms at play and the effects of leucine on brain health. Participants may undergo assessments related to their brain function and mood.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of major depression.
Not a fit: Patients under the age of 65 or those without depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for depression in older adults by targeting specific biochemical pathways.
How similar studies have performed: Previous research has shown promising results in using similar approaches to address depression and brain health, indicating potential for success in this study.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAROON, EBRAHIM — EMORY UNIVERSITY
- Study coordinator: HAROON, EBRAHIM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.