Investigating how lead exposure and genetics contribute to Alzheimer's disease in aging brains
Official title: Elucidate Gene-environmental interactions employed by Pb in promoting ADRD in aging brains
Funded at Purdue University · NIH-10973790 · Data updated 2026-11-12
This study is looking at how being exposed to lead when we're young might affect our brain health as we get older, especially for those at risk of Alzheimer's and related dementias, and it aims to find out how our genes might make some people more vulnerable to these effects.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $784,998 |
| NIH project number | 1U01AG088662-01 |
| Project ID | NIH-10973790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of lead exposure and those at risk for Alzheimer's disease due to genetic factors.
✕Less likely to help
Patients who do not have a history of lead exposure or genetic predisposition to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the interactions between genetic factors and environmental stressors, specifically lead exposure, in the development of Alzheimer's disease and related dementias (ADRD). It aims to understand how lead exposure during critical developmental periods can lead to neurological issues later in life, particularly as individuals age. By using human neuronal models, the study will identify genetic risk factors that may exacerbate the effects of lead on brain health. The research employs advanced techniques to analyze neuronal changes and aging markers, providing insights into the biological mechanisms at play.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease and related dementias, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the impact of environmental factors on neurological diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Yuan, Chongli — Purdue University
- Study coordinator: Yuan, Chongli
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.