Investigating how lead exposure affects the brain and gut health in children
Evaluation of Pb-induced perturbations in the central and enteric nervous system
This study looks at how lead exposure from things like contaminated drinking water affects children's brains and gut health, aiming to understand how these two areas are connected and how they might impact each other.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11003710 on NIH RePORTER |
What this research studies
This research examines the impact of lead (Pb) exposure on the central and enteric nervous systems, particularly in children who are more susceptible to its harmful effects. The study focuses on how lead, often found in contaminated drinking water, alters gut microbiota and contributes to neurological deficits. By exploring the gut-brain axis, the research aims to understand the relationship between gut health and brain development in the context of lead exposure. The methodology includes analyzing changes in gut microbiota and their potential role in neurological outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children exposed to lead through contaminated drinking water, particularly those showing signs of neurological impairment.
Not a fit: Patients who have not been exposed to lead or do not exhibit any neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for neurological deficits caused by lead exposure in children.
How similar studies have performed: Previous research has indicated that alterations in gut microbiota can influence neurological health, suggesting that this approach may yield valuable insights.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Morton, Paul David — Virginia Polytechnic Inst and St Univ
- Study coordinator: Morton, Paul David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.