Investigating how lead exposure affects memory through RNA modifications
Official title: The Role of m6A-RNA Methylation in Memory Formation and Recall and Its Modulation and Influence on Long-Term Outcomes as a Consequence of Early Life Lead Exposure
Funded at Thomas Jefferson University · NIH-11078266 · Data updated 2026-11-12
This study is looking at how being exposed to lead when they were young might affect children's memory and learning, by checking out a special change in their RNA, and it aims to help us understand how such exposure can impact their brain development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $549,132 |
| NIH project number | 5R01ES034077-03 |
| Project ID | NIH-11078266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been exposed to lead.
✕Less likely to help
Patients who have not been exposed to lead or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research explores the impact of early life lead exposure on memory formation and recall by examining the role of a specific RNA modification known as m6A. The study aims to understand how changes in RNA methylation can influence cognitive and behavioral outcomes in children who have been exposed to lead. By using animal models, researchers will analyze the effects of lead on brain regions associated with memory and learning, focusing on the underlying molecular mechanisms. The findings could provide insights into how environmental factors affect brain development and function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for cognitive and behavioral deficits in children exposed to lead.
How similar studies have gone: Previous research has shown promising results in understanding the effects of environmental toxins on neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Schneider, Jay S — Thomas Jefferson University
- Study coordinator: Schneider, Jay S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.