Investigating how lead exposure affects memory through RNA modifications
The Role of m6A-RNA Methylation in Memory Formation and Recall and Its Modulation and Influence on Long-Term Outcomes as a Consequence of Early Life Lead Exposure
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-11078266
This study is looking at how being exposed to lead when they were young might affect children's memory and learning, by checking out a special change in their RNA, and it aims to help us understand how such exposure can impact their brain development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11078266 on ClinicalTrials.gov |
What this research studies
This research explores the impact of early life lead exposure on memory formation and recall by examining the role of a specific RNA modification known as m6A. The study aims to understand how changes in RNA methylation can influence cognitive and behavioral outcomes in children who have been exposed to lead. By using animal models, researchers will analyze the effects of lead on brain regions associated with memory and learning, focusing on the underlying molecular mechanisms. The findings could provide insights into how environmental factors affect brain development and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been exposed to lead.
Not a fit: Patients who have not been exposed to lead or are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for cognitive and behavioral deficits in children exposed to lead.
How similar studies have performed: Previous research has shown promising results in understanding the effects of environmental toxins on neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNEIDER, JAY S — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: SCHNEIDER, JAY S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.