Investigating how Layilin affects platelet activation and inflammation in blood disorders
The Role of Layilin as a Novel Regulator of Platelet Activation and Thromboinflammation
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-11079494
This study is looking at how a protein called Layilin affects blood platelets and inflammation in people with inflammatory bowel disease (IBD), to help find better ways to treat the risks of blood clots that can happen with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11079494 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of Layilin in regulating platelet activation and thromboinflammation, particularly in patients with inflammatory bowel disease (IBD). It aims to explore the molecular pathways that lead to increased platelet reactivity and the associated risks of thromboembolism, which can be life-threatening. By analyzing blood samples from IBD patients, the study seeks to identify how platelets contribute to inflammation and clotting, potentially leading to new treatment strategies. The research will involve both laboratory assays and clinical observations to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Not a fit: Patients without inflammatory bowel disease or those with other unrelated blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for IBD patients by addressing the risks of blood clots and inflammation.
How similar studies have performed: Previous research has shown that understanding platelet function in inflammatory conditions can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETREY, AARON CHRISTOPHER — UNIVERSITY OF UTAH
- Study coordinator: PETREY, AARON CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.