Investigating how Layilin affects platelet activation and inflammation in blood disorders
Official title: The Role of Layilin as a Novel Regulator of Platelet Activation and Thromboinflammation
Funded at University of Utah · NIH-11079494 · Data updated 2026-11-12
This study is looking at how a protein called Layilin affects blood platelets and inflammation in people with inflammatory bowel disease (IBD), to help find better ways to treat the risks of blood clots that can happen with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $665,102 |
| NIH project number | 5R01HL167919-03 |
| Project ID | NIH-11079494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients without inflammatory bowel disease or those with other unrelated blood disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of Layilin in regulating platelet activation and thromboinflammation, particularly in patients with inflammatory bowel disease (IBD). It aims to explore the molecular pathways that lead to increased platelet reactivity and the associated risks of thromboembolism, which can be life-threatening. By analyzing blood samples from IBD patients, the study seeks to identify how platelets contribute to inflammation and clotting, potentially leading to new treatment strategies. The research will involve both laboratory assays and clinical observations to gather comprehensive data.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for IBD patients by addressing the risks of blood clots and inflammation.
How similar studies have gone: Previous research has shown that understanding platelet function in inflammatory conditions can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Petrey, Aaron Christopher — University of Utah
- Study coordinator: Petrey, Aaron Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.