Investigating how late onset unexplained epilepsy affects cognitive decline and interacts with Alzheimer's disease.
The Contribution of Late Onset Unexplained Epilepsy to Cognitive Decline and its Interaction with Vascular and Alzheimer's Disease Pathologies
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10872325
This study is looking at how late-onset unexplained epilepsy affects thinking and memory in older adults, and it’s for people who have this type of epilepsy; we want to learn more about what causes it and how it relates to common age-related brain issues, so we can find better ways to help.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10872325 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of late onset unexplained epilepsy (LOUE) on cognitive decline in older adults. It aims to identify the underlying factors contributing to LOUE and how these factors relate to common aging-related pathologies, such as Alzheimer's disease and small vessel ischemic disease. The study will recruit a cohort of 100 individuals with LOUE and follow them over three years to assess changes in cognition and neurodegeneration. By utilizing MRI and blood biomarkers, the research seeks to develop preventive and therapeutic strategies for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with late onset unexplained epilepsy.
Not a fit: Patients who do not have late onset unexplained epilepsy or are younger than 65 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive decline in older adults with epilepsy, potentially enhancing their quality of life.
How similar studies have performed: Previous research has indicated a correlation between late onset epilepsy and increased risk of cognitive decline, suggesting that this approach has potential for meaningful insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARKIS, RANI — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SARKIS, RANI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.