Investigating how large DNA repair proteins work
Structural Biology Studies of a Large DNA Repair Complex
This study is looking at how big proteins that help fix DNA work and how changes in these proteins might be linked to diseases like cancer and neurological disorders, so we can find better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11141597 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of large proteins that bind to DNA, particularly those involved in repairing DNA damage. Using advanced techniques like nuclear magnetic resonance (NMR) spectroscopy, the team examines how these proteins interact and function in the body. By studying mutations that affect these proteins, the research aims to uncover how they contribute to diseases, including various cancers and neurological disorders. Patients may benefit from insights gained about DNA repair mechanisms and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mutations in DNA repair proteins or those affected by related cancers and neurological disorders.
Not a fit: Patients with conditions unrelated to DNA repair mechanisms or those without genetic mutations affecting these proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cancers and diseases related to DNA damage.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, making this approach promising and relevant.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Latham, Michael Parker — University of Minnesota
- Study coordinator: Latham, Michael Parker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.