Investigating how Lamp1 and lipid transport affect cell function in aging
The role of Lamp1 and lipid transport in the regulation of vesicle identity
This study is looking at how a protein called Lamp1 affects the movement of fats and other important substances in our cells, especially as we age or if we have conditions like Alzheimer's or Parkinson's, to find ways to keep our brain cells healthy and possibly help older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11018597 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Lamp1, a protein involved in the transport of lipids and other substances within cells, particularly in the context of aging and neurodegenerative diseases like Alzheimer's and Parkinson's. The study examines how disruptions in lipid transport and lysosomal function can lead to the accumulation of harmful protein aggregates that damage neurons. By using model organisms, the researchers aim to uncover the mechanisms behind these processes and identify potential therapeutic targets to improve cellular health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing symptoms related to neurodegenerative diseases or age-related decline in cellular function.
Not a fit: Patients under the age of 65 or those without any signs of neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cellular function and protect against neurodegenerative diseases in older adults.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function and lipid metabolism in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Jenny, Andreas — Albert Einstein College of Medicine
- Study coordinator: Jenny, Andreas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.