Investigating how Lamp1 and lipid transport affect cell function in aging
Official title: The role of Lamp1 and lipid transport in the regulation of vesicle identity
Funded at Albert Einstein College of Medicine · NIH-11018597 · Data updated 2026-11-12
This study is looking at how a protein called Lamp1 affects the movement of fats and other important substances in our cells, especially as we age or if we have conditions like Alzheimer's or Parkinson's, to find ways to keep our brain cells healthy and possibly help older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $540,987 |
| NIH project number | 5R01AG081283-02 |
| Project ID | NIH-11018597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing symptoms related to neurodegenerative diseases or age-related decline in cellular function.
✕Less likely to help
Patients under the age of 65 or those without any signs of neurodegenerative diseases may not benefit from this research.
What this research studies
This research focuses on understanding the role of Lamp1, a protein involved in the transport of lipids and other substances within cells, particularly in the context of aging and neurodegenerative diseases like Alzheimer's and Parkinson's. The study examines how disruptions in lipid transport and lysosomal function can lead to the accumulation of harmful protein aggregates that damage neurons. By using model organisms, the researchers aim to uncover the mechanisms behind these processes and identify potential therapeutic targets to improve cellular health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cellular function and protect against neurodegenerative diseases in older adults.
How similar studies have gone: Previous research has shown promising results in understanding lysosomal function and lipid metabolism in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Jenny, Andreas — Albert Einstein College of Medicine
- Study coordinator: Jenny, Andreas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.