Investigating how L-2-hydroxyglutarate affects heart function during low oxygen conditions
L-2-Hydroxyglutarate and Metabolic Remodeling in Hypoxia
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11047846
This study is looking at how a substance called L-2-hydroxyglutarate might help protect heart cells from damage when they don't get enough oxygen, and it's aimed at finding new ways to keep your heart healthy during tough times.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11047846 on ClinicalTrials.gov |
What this research studies
This research explores the effects of L-2-hydroxyglutarate (L2HG) on heart cells during periods of low oxygen (hypoxia) and how it may help protect these cells from damage. The study focuses on understanding the metabolic changes that occur in heart cells when they are deprived of oxygen and how certain metabolites, like branched-chain ketoacids, can enhance cellular protection. By examining these metabolic pathways, the research aims to identify new strategies to improve heart function and reduce injury during ischemic events.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with conditions that lead to reduced blood flow to the heart, such as coronary artery disease or heart attacks.
Not a fit: Patients with stable heart conditions that do not involve ischemia or hypoxia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage during low oxygen conditions, potentially improving outcomes for patients with heart disease.
How similar studies have performed: Previous research has shown promising results in understanding metabolic responses to hypoxia, suggesting that this approach may yield significant insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOSCALZO, JOSEPH — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: LOSCALZO, JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.