Investigating how kynurenine affects bone mass and kidney function in aging
Kynurenine: a potential link between age-related decreases in bone mass and kidney function
This study is looking at how a substance called kynurenine might affect bone health and kidney function in older adults, helping us understand how aging impacts these important areas and potentially leading to better ways to support bone and kidney health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11042695 on NIH RePORTER |
What this research studies
This research explores the relationship between kynurenine levels and bone loss as well as kidney dysfunction in older adults. It focuses on understanding how aging impacts kidney function, which is crucial for maintaining bone health through Vitamin D synthesis and calcium regulation. The study will involve experiments that assess the effects of kynurenine on bone marrow stem cell proliferation and its potential role in inducing age-related changes in bone and kidney health. By examining these mechanisms, the research aims to uncover new insights into osteoporosis and kidney health in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing bone density loss or kidney function decline.
Not a fit: Patients who are younger or do not have issues related to bone density or kidney function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing bone loss and improving kidney function in older adults.
How similar studies have performed: Previous research has indicated that understanding the interplay between kidney function and bone health can lead to significant advancements in treating osteoporosis, suggesting this approach has potential for success.
Where this research is happening
Augusta, United States
- Charlie Norwood VA Medical Center — Augusta, United States (Active)
Researchers
- Principal investigator: Irsik, Debra — Charlie Norwood VA Medical Center
- Study coordinator: Irsik, Debra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.