Investigating how kynurenine affects aging and frailty
Linking kynurenine accumulation and the AHR pathway to exacerbated aging
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11017729
This study is looking at how a substance called kynurenine, which builds up in our blood as we get older, might affect muscle strength and overall health in older adults, with the goal of finding ways to help keep you strong and active as you age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11017729 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between kynurenine, a compound that accumulates in the blood as we age, and its impact on physical frailty in older adults. The study aims to understand how elevated levels of kynurenine may lead to muscle atrophy and mitochondrial dysfunction, which are key factors in frailty. By examining the role of the aryl hydrocarbon receptor (AHR) in this process, researchers hope to uncover potential therapeutic targets that could mitigate the effects of aging on physical health. Patients may be involved in studies assessing muscle function and metabolic changes related to kynurenine levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing signs of physical frailty or age-related decline.
Not a fit: Patients who are not elderly or do not exhibit signs of frailty may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve physical function and reduce frailty in older adults.
How similar studies have performed: While the specific approach of linking kynurenine to frailty is novel, related research has shown that targeting metabolic pathways can improve outcomes in aging populations.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RYAN, TERENCE E — UNIVERSITY OF FLORIDA
- Study coordinator: RYAN, TERENCE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.