Investigating how Kv2.1 channels affect neuron communication and health
Neuronal Cell Biology of Kv2.1-induced Endoplasmic Reticulum/Plasma Membrane Contact sites
['FUNDING_R01'] · COLORADO STATE UNIVERSITY · NIH-10771974
This study is looking at a special channel in brain cells that helps control electrical signals and keeps the cells healthy, and it aims to find out how this channel works under different conditions, which could help us understand and improve treatments for people with developmental delays and other brain-related issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLORADO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (FORT COLLINS, UNITED STATES) |
| Trial ID | NIH-10771974 on ClinicalTrials.gov |
What this research studies
This research focuses on the Kv2.1 potassium channel, which plays a crucial role in neuron function by regulating electrical signals in the brain. The study aims to understand how Kv2.1 forms contact sites between the endoplasmic reticulum and plasma membrane in neurons, which are essential for maintaining calcium levels and overall neuronal health. By examining these interactions, the research seeks to uncover how neuronal activity and stress conditions, like hypoxia, influence these contact sites and their impact on neuron behavior. Patients may benefit from insights into how disruptions in these processes could lead to developmental delays and other neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing developmental delays or specific child development disorders.
Not a fit: Patients with conditions unrelated to neuronal function or development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating developmental delays and other neurological conditions.
How similar studies have performed: Other research has shown promising results in understanding the role of ion channels in neuronal health, suggesting that this approach could yield valuable insights.
Where this research is happening
FORT COLLINS, UNITED STATES
- COLORADO STATE UNIVERSITY — FORT COLLINS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAMKUN, MICHAEL M. — COLORADO STATE UNIVERSITY
- Study coordinator: TAMKUN, MICHAEL M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.